Vinpocetine (VNP) is a nootropic agent used in cerebrovascular disorders and dementia. Its bioavailability is irregular and irreproducible, due to its low solubility in the intestine and extensive first pass metabolism. The objective of our work was to prepare VNP in a self-nano-emulsifying drug delivery system (SNEDDS) and then convert it into solid-SNEDDS (S-SNEDDS) that have acceptable characteristics for tablet compression. Those tablets could be transformed into osmotic systems to control the drug release. SNEDDS composed of 10% Maisine™ 35-1, 50% Cremophor® EL and 40% Transcutol® HP was the system of choice with drug to system ratio of 2.5 mg: 0.25 gm. Its particle size was 16.97±0.32 nm and zeta potential was -12.65±4.39 mV. S-SNEDDS, loaded on Aeroperl®, possessed good flow properties; angle of repose (26.02±0.79), Hausner’s ratio (1.067±0.02) and compressibility index (6.347% ±1.37). Elementary osmotic pump (EOP) tablets and controlled porosity osmotic pump tablets (CPOP) were prepared and the in-vitro release of VNP from both systems showed promising results. Therefore, VNP loaded S-SNEDDS was successfully prepared with improved VNP solubility which might resolve its bioavailability problem then formulated into osmotically controlled dosage form to control drug release.
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